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Cyclobutane Derivatives as Potent NK1 Selective Antagonists.

✍ Scribed by Michelle Laci Wrobleski; Gregory A. Reichard; Sunil Paliwal; Sapna Shah; Hon-Chung Tsui; Ruth A. Duffy; Jean E. Lachowicz; Cynthia A. Morgan; Geoffrey B. Varty; Neng-Yang Shih

Publisher
John Wiley and Sons
Year
2006
Weight
12 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract The airways' pharmacology of DNK333 ((1R,3R,2E)‐N‐[3,4‐dichlorobenzyl)]‐4‐[(hexahydro‐2‐oxo‐1H‐azepin‐3‐yl)amino]‐N‐methyl‐3,5bis(trifluoromethyl) benzamide), a potent and selective dual NK~1~/NK~2~ neurokinin receptor antagonist is described in the present paper. DNK333 bound with high