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Cyclobenzaprine overdose: The importance of a clinical history in analytical toxicology

✍ Scribed by Kevin S. Merigian; Timothy J. Schoeder; Jerry J. Tasset; Amadeo J. Pesce

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
419 KB
Volume
1
Category
Article
ISSN
0887-8013

No coin nor oath required. For personal study only.

✦ Synopsis

Clinicians have become increasingly de-formance liquid chromatography, EMIT pendent on advanced analytical technol-enzyme immunoassay, and gas chromaogy to supplement their diagnostic im-tography-mass spectrometry could not pression of comatose patients. We report distinguish between the two compounds. a comatose patient who had ingested cy-An additional investigation of urine speciclobenzaprine, penatazocine, and eth-mens from four volunteers who took 1) 50 chlorvinyl. The cyclobenzaprine was mismg of amitriptyline, 2) 20 mg of cyclobentakenly identified as amitriptyline. Struc-zaprine, and 3) both 50 mg of amitriptyline turally these two agents are very similar and 20 mg of cyclobenzaprine was unable with the exception of one double bond at to distinguish the two agents. These rethe central aromatic group. The techsults serve to reinforce the necessity of a niques of conventional thin-layer chroma-clinical history taken in conjunction with tography, high-efficiency thin-layer chro-analytical techniques before identifying pomatography, Toxi-Lab thin-layer chroma-tential agents present in various biological tography, gas chromatography, high-per-material.

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