Cycloaddition–hydrogenolysis strategy for the synthesis of 2,4-disubstituted pyroglutamates

✍ Scribed by Lalit N Goswami; Stuti Srivastava; Sharad K Panday; Dinesh K Dikshit

• Book ID: 104231677
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 48 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01629-x

✦ Synopsis

1,3-Dipolar addition of amino acid derived dipoles with menthyl acrylate followed by hydrogenolysis of the adduct gives chiral 2-a-substituted-4-a-arylmethyl-pyroglutamates.