Cycloaddition reactions of vinylcephalosporins with diazoalkanes
✍ Scribed by János Pitlik; István Miskolczi; Katalin E. Kövér; Csaba J. Jászberényi; Ferenc Sztaricskai
- Book ID
- 104229788
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 180 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Isonitriles react with carbenes to give @-adducts, keteneimines. 1) Further cycloaddition of isonitriles to keteneimines is expected when the substituents of them are aromatic. From this point of view, reaction of several aromatic isonitriles with diazoalkanes as the precursors of carbene was examin
## Abstract The 2‐methylenecephalosporins 1 undergo stereoselective 1,3‐dipolar cycloaddition reactions with diazoalkanes to give exclusively the spirocyclopropylcephalosporins 3. Substituens at C‐3, C‐4 and C‐7 of the cephalosporin nucleus do not display a significant effect on the reactivity of t