Cyclo-oxygenase-2 Plays a Critical Role in UV-induced Skin Carcinogenesis
β Scribed by Joyce E. Rundhaug; Susan M. Fischer
- Book ID
- 111413153
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 356 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0031-8655
No coin nor oath required. For personal study only.
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## Abstract UVB irradiation of epidermal keratinocytes results in the activation of the p38 mitogenβactivated protein kinase (MAPK) pathway and subsequently activator proteinβ1 (APβ1) transcription factor activation and cyclooxygenaseβ2 (COXβ2) expression. APβ1 and COXβ2 have been shown to play fun
## Abstract Nonmelanoma skin cancer is the most prevalent cancer in the United States and its incidence is on the rise. These cancers generally arise on sunβexposed areas of the body and the ultraviolet (UV) B spectrum of sunlight has been clearly identified as the major carcinogen responsible for