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Cyclizations of β-Chloroethyl Substituted Ammonocarbonic Acids

✍ Scribed by McKay, A. F.; Braun, R. O.


Book ID
125929813
Publisher
American Chemical Society
Year
1951
Tongue
English
Weight
384 KB
Volume
16
Category
Article
ISSN
0022-3263

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The first examples of Lewis acid-catalyzed chelation-controlled cyclization reactions are reported. Titanium tetrachloride-initiated cyclization of 8-ketoester and S-ketoamide-substituted allylsilanes proceeds in isolated yields of 65-88X, providing a single diastereomeric product in each case.