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Cyclization of N1-aryl-N3-acetyl-p-nitrobenzamidrazones to substituted 1,2,4-triazoles

โœ Scribed by M. O. Lozinskii; T. N. Kudrya; S. V. Bonadyk; P. S. Pel'kis


Book ID
112333018
Publisher
Springer US
Year
1977
Tongue
English
Weight
338 KB
Volume
13
Category
Article
ISSN
0009-3122

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Rapid, microwave-assisted synthesis of N
โœ Jerry Meng; Pei-Pei Kung ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 225 KB

A robust, regioselective synthesis of 3-amino-1,2,4-triazoles is described. This reaction employs a key intermediate 2, which is coupled to carboxylic acids in good yields to afford intermediates 3a-d. These entities, in turn, react with a variety of hydrazines or hydrazine hydrochlorides to provide