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Cyclization of diketones to pyridazine and furan derivatives

✍ Scribed by Hassan M. Faid Allah; Raafat Soliman


Book ID
112128778
Publisher
Journal of Heterocyclic Chemistry
Year
1987
Tongue
English
Weight
222 KB
Volume
24
Category
Article
ISSN
0022-152X

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Anionic Cyclizations of Pentynones and H
✍ Thomas Nicola; Ralf Vieser; Wolfgang Eberbach πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 400 KB

On treatment with base the pentynones 8a؊f undergo anionic addition reactions of the resulting enolate species to the alkyne moiety and afford the 2,5-disubstituted furans 10a؊f in yields ranging from 10Οͺ91%. The proposed mechanism involves the 2-methylene-dihydrofurans 11 as intermediates which tau