✦ LIBER ✦

Cyclisation of histidine containing peptides in the solid-phase by anchoring the imidazole ring to trityl resins

✍ Scribed by Giuseppina Sabatino; Mario Chelli; Silvia Mazzucco; Mauro Ginanneschi; Anna Maria Papini

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 284 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)02459-9

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✦ Synopsis

Head-to-tail histidine containing cyclopeptides can be efficiently synthesised by a three-dimensional orthogonal solid-phase strategy (Fmoc/tBu/allyl) v/a anchoring the imidazole ring to trityi-resins. Furthermore, Fmoc-His(Trt-®)-OAl can be a useful starting support for the preparation of diketopiperazine combinatorial libraries.