Inactivation of p53 in normal human cell
✍
Jocelyn Céraline; Gaël Deplanque; Brigitte Duclos; Jean-Marc Limacher; Amor Hajr
📂
Article
📅
1998
🏛
John Wiley and Sons
🌐
French
⚖ 206 KB
👁 2 views
p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we sh