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Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery

✍ Scribed by Kimura, Shinya H; Ikawa, Masahito; Ito, Akihiko; Okabe, Masaru; Nojima, Hiroshi


Book ID
110064561
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
636 KB
Volume
20
Category
Article
ISSN
0950-9232

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p53 mutations are found in about 70% of human cancers. In order to evaluate the role of these mutations in response to chemotherapeutic agents, it is important to distinguish between p53 response to DNA-damaging agents in normal and in tumour cells. Here, using normal human fibroblasts (NHFs), we sh