The E6 gene of tumor-associated types of human papillomaviruses codes for a functional antagonist of p53. Overexpression of E6 from heterologous promoters can block p53-mediated cellular responses to DNA damage, such as transcriptional stimulation of p53 target genes and cell-cycle arrest in GI. In
β¦ LIBER β¦
Cyclin E induction by genotoxic stress leads to apoptosis of hematopoietic cells
β Scribed by Mazumder, Suparna; Gong, Bendi; Almasan, Alexandru
- Book ID
- 110063947
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 291 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0950-9232
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