To validate a proposed solid support synthesis strategy for the construction of 2,6,9-trisubstituted purine based CDK inhibitors, the N-9 THP protected 6-benzylthio-2-iodopurine 11 was reacted with piperidine-2-methanol to give 12. Alternatively, intermediate 11 was converted to the C-2 acetylenyl s
โฆ LIBER โฆ
Cyclin-dependent kinase (CDK) inhibitors: development of a general strategy for the construction of 2,6,9-trisubstituted purine libraries. Part 2
โ Scribed by Virginie Brun; Michel Legraverend; David S Grierson
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 165 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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