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Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2

โœ Scribed by Wang, C X; Song, J H; Song, D K; Yong, V W; Shuaib, A; Hao, C


Book ID
110017106
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
514 KB
Volume
13
Category
Article
ISSN
1350-9047

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Regulation of cyclin-dependent kinase 5
โœ Jong-Hee Lee; Kyong-Tai Kim ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 572 KB

## Abstract DNA damage is known to be an initiator of neuronal death in neurodegenerative conditions such as Parkinson's and Alzheimer's diseases. The mechanism linking DNA damage and neuronal death is not completely understood. Here, we delineate the mechanism by which neuronal death evoked by DNA