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Cyclin dependent kinase 5 (Cdk5) mediated inhibition of the MAP kinase pathway results in CREB down regulation and apoptosis in PC12 cells

✍ Scribed by Monica Sharma; Naresh Kumar Hanchate; Rakesh K. Tyagi; Pushkar Sharma


Book ID
116294915
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
252 KB
Volume
358
Category
Article
ISSN
0006-291X

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## Abstract Multiple myeloma (MM) is a malignancy characterized by the accumulation of tumoral plasma cells in bone marrow. This disease remains incurable and the development of new therapeutic strategies is urgently required. We have studied the effects of 2 selective estrogen receptor disrupters