Cyclin Dependent Kinase 5 (Cdk5)

✍ Scribed by Toshio Ohshima (auth.), Li-Huei Tsai, Nancy Y. Ip (eds.)

Publisher: Springer US
Year: 2008
Tongue: English
Leaves: 342
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.

✦ Table of Contents

Front Matter....Pages i-xvi
Cdk5/p35 Regulates Neuronal Migration....Pages 1-8
CRMP Family Protein: Novel Targets for Cdk5 That Regulates Axon Guidance, Synapse Maturation, and Cell Migration....Pages 9-24
Cdk5 in Presynapses....Pages 25-33
Cyclin-Dependent Kinase 5: A Critical Regulator of Neurotransmitter Release....Pages 35-50
Cdk5 in Dendrite and Synapse Development: Emerging Role as a Modulator of Receptor Tyrosine Kinase Signaling....Pages 51-68
Cyclin-Dependent Kinase 5 (Cdk5) Modulates Signal Transduction Pathways Regulating Neuronal Survival....Pages 69-90
CDK5 and Mitochondrial Cell Death Pathways....Pages 91-106
Regulation and Function of Cdk5 in the Nucleus....Pages 107-118
Cdk5 May Be an Atypical Kinase, but Not in the Way You Think....Pages 119-137
Cdk5 and Neuregulin-1 Signaling....Pages 139-144
Cyclin-Dependent Kinase 5 and Insulin Secretion....Pages 145-158
Protein–Protein Interactions Involving the N-Terminus of p35....Pages 159-170
The Kinase Activity of Cdk5 and Its Regulation....Pages 171-190
The Structural Bases of CDK5 Activity....Pages 191-210
Cdk5, a Journey from Brain to Pain: Lessons from Gene Targeting....Pages 211-226
Involvement of Cdk5 in Synaptic Plasticity, and Learning and Memory....Pages 227-260
Cyclin-Dependent Kinase 5 (Cdk5): Linking Synaptic Plasticity and Neurodegeneration....Pages 261-282
Cdk5 as a Drug Target for Alzheimer’s Disease....Pages 283-299
Back Matter....Pages 301-329

✦ Subjects

Neurosciences; Cell Biology; Developmental Biology

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