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Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells

✍ Scribed by Sweeney, Kimberley J; Sarcevic, Boris; Sutherland, Robert L; Musgrove, Elizabeth A

Book ID: 110060587
Publisher: Nature Publishing Group
Year: 1997
Tongue: English
Weight: 564 KB
Volume: 14
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1200951

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## Abstract Alternative splicing in the __cyclin D1__ gene produces __cyclin D1b__ variant which lacks a C‐terminal region containing the threonine‐286 (T286) phosphorylation site required for nuclear export. We have shown that the expression of the __cyclin D1b__ variant is detected in about 60% o