Cyclin D1/PRAD1 as a central target in oncogenesis
โ Scribed by Yoshitaka Hosokawa; Andrew Arnold
- Book ID
- 114053800
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 731 KB
- Volume
- 127
- Category
- Article
- ISSN
- 1532-6543
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Background. Abnormalities in chromosome llq13 regions have been frequently found in head and neck squamous carcinoma. Recent studies indicate that the PRAD-1 (also CCNDI), which encodes cyclin D1, is a putative oncogene that is an important component of this region. Methods. DNA was extracted
The cyclin D1/CCND1 oncogene (PRAD1) is amplified in 15% of primary human breast cancers and overexpressed in 30-50% of breast cancers, suggesting that mechanisms in addition to DNA amplification may lead to deregulated expression of this gene in breast cancer. Cyclin D1 overexpression at a higher f