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Cyclin D1 overexpression combined with N-nitrosomethylbenzylamine increases dysplasia and cellular proliferation in murine esophageal squamous epithelium

✍ Scribed by Jenkins, Timothy D; Mueller, Annegret; Odze, Robert; Shahsafaei, Aliakbar; Zukerberg, Lawrence R; Kent, Ralph; Stoner, Gary D; Rustgi, Anil K

Book ID: 110061755
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 858 KB
Volume: 18
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1202296

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## Abstract The cyclin D1 oncogene is frequently amplified/overexpressed in oral squamous cell carcinomas. Mice with overexpression of cyclin D1 targeted to the stratified squamous epithelia of the tongue, esophagus, and forestomach develop a phenotype of epithelial dysplasia at these sites. In thi