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Cyclin D1 as a cellular proto-oncogene

โœ Scribed by Stewart Bates; Gordon Peters


Book ID
112264805
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
68 KB
Volume
6
Category
Article
ISSN
1044-579X

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## Abstract Perturbations in the regulation of the core cell cycle machinery are frequently observed in human cancers. Cyclin D1 which functions as a mitogenic sensor and allosteric activator of CDK4/6, is one of the more frequently altered cell cycle regulators in cancers. Cyclin D1 is frequently