## Abstract Polysialic acid (PSA) is highly expressed in many human cancers, including neuroblastoma (NB), and is critical for cellular adhesion, neuronal migration and tumor metastasis. The key enzyme responsible for PSA synthesis is sialyltransferase STX (ST8SiaII). Using quantitative RTβPCR we (
Cyclin D1, a Novel Molecular Marker of Minimal Residual Disease, in Metastatic Neuroblastoma
β Scribed by Cheung, Irene Y.; Feng, Yi; Vickers, Andrew; Gerald, William; Cheung, Nai-Kong V.
- Book ID
- 122530536
- Publisher
- American Society for Investigative Pathology
- Year
- 2007
- Tongue
- English
- Weight
- 193 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1525-1578
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## Abstract In mantle cell lymphoma (MCL), minimal residual disease (MRD) is an indicator of the disease outcome. Quantitative methods used so far do not provide a suitable molecular marker in 30β70% patients with MCL (depending on the technique used). We tested cyclin D1 as a marker for quantitati
Background. We have determined whether sequential molecular detection of minimal residual disease (MRD) in bone marrow (BM) could predict the outcome of patients with advanced neuroblastoma (NB). Procedure. Bone marrow samples from 19 patients over 12 months of age with stage 4 neuroblastoma were se