Cyclin A is a prognostic indicator in early stage breast cancer with and without tamoxifen treatment
β Scribed by Michalides, R; van Tinteren, H; Balkenende, A; Vermorken, J B; Benraadt, J; Huldij, J; van Diest, P
- Book ID
- 109997125
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 127 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0007-0920
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## Abstract ## BACKGROUND: Fareston (toremifene) and tamoxifen, both selective estrogen receptor modulators, are therapeutically equivalent treatments for metastatic breast cancer. We hypothesized that toremifene as compared with tamoxifen given as adjuvant therapy for early stage breast cancer wo
A displacement assay with tamoxifen, based on the relative binding affinity of tamoxifen and estradiol for the estrogen receptor (ER), was proposed in 1990 as prognostic indicator for breast-cancer patients. Validation of its predictive results in relation to the outcome of 73 patients with ER Ψ tum