✦ LIBER ✦

Cyclic trimer of 5-(aminomethyl)-2-furancarboxylic acid as a novel synthetic receptor for carboxylate recognition

✍ Scribed by Tushar K Chakraborty; Subhasish Tapadar; S Kiran Kumar

Book ID: 104232407
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 110 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)02367-x

No coin nor oath required. For personal study only.

✦ Synopsis

A novel 18-membered cyclic oligopeptide 1 based on 5-(aminomethyl)-2-furancarboxylic acid (2), is developed as an excellent receptor for carboxylate binding having an association constant of 8.64×10 3 M -1 for tetrabutylammonium acetate in CD 3 CN. The synthesis of 1 was achieved by a high-yielding cyclotrimerization reaction of the unfunctionalized furan amino acid 2.

📜 SIMILAR VOLUMES

Structure—Activity Relationships of 2-Su

Structure—Activity Relationships of 2-Substituted 5,7-Diarylcyclopenteno[1,2-b]pyridine-6-carboxylic Acids as a Novel Class of Endothelin Receptor Antagonists.

✍ Kenji Niiyama; et al. et al. 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 213 KB 👁 1 views

Design, Synthesis, and Pharmacological E

Design, Synthesis, and Pharmacological Evaluation of Novel 2-(4-substituted piperazin-1-yl)1, 8 Naphthyridine 3-Carboxylic Acids as 5-HT 3 Receptor Antagonists for the Management of Depression

✍ Dhar, Arghya K.; Mahesh, Radhakrishnan; Jindal, Ankur; Devadoss, Thangaraj; Bhat 📂 Article 📅 2014 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB

ChemInform Abstract: New Cyclic Butyroph

ChemInform Abstract: New Cyclic Butyrophenone Derivatives in the Indole Series as Potential Atypical Antipsychotics. A Simple and Practical Synthesis of 6- Aminomethyl-tetrahydroindol-4-ones and Their Affinities for D2 and 5- HT2A Receptors.

✍ C. F. MASAGUER; E. RAVINA; I. LOZA; J. A. FONTENLA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

Synthesis and Biological Evaluation of A

Synthesis and Biological Evaluation of Analogues of 7-Chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5- a ]quinoxaline-2-carboxylic Acid (TQX-173) as Novel Selective AMPA Receptor Antagonists

✍ Catarzi, Daniela; Colotta, Vittoria; Varano, Flavia; Calabri, Francesca Romana; 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 177 KB

ChemInform Abstract: Synthesis and Biolo

ChemInform Abstract: Synthesis and Biological Evaluation of Novel 9-Heteroaryl Substituted 7-Chloro-4,5-dihydro-4-oxo-1,2,4-triazolo [1,5-a]quinoxaline-2-carboxylates (TQX) as (R,S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptor Antagonists.

✍ Daniela Catarzi; Vittoria Colotta; Flavia Varano; Guido Filacchioni; Paola Gratt 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 45 KB 👁 1 views

Structure−Activity Relationships of a No

Structure−Activity Relationships of a Novel Class of Endothelin-A Receptor Antagonists and Discovery of Potent and Selective Receptor Antagonist, 2-(Benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2 H -chromene-3- carboxylic Acid (S-1255). 1. Study on Structure−Activity Relationships and Basic Structure Crucial for ET A Antagonism

✍ Ishizuka, Natsuki; Matsumura, Ken-ichi; Sakai, Katsunori; Fujimoto, Masafumi; Mi 📂 Article 📅 2002 🏛 American Chemical Society 🌐 English ⚖ 186 KB