Cyclic peptides revisited

✍ Scribed by Vincent Madison

• Book ID: 101720678
• Publisher: Wiley (John Wiley & Sons)
• Year: 1985
• Tongue: English
• Weight: 302 KB
• Volume: 24
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.360240109

✦ Synopsis

A multistep computational scheme was used to deduce possible conformations for a cyclic antagonist analog of somatostatin that has been reported by Coy and coworkers. An algebraic algorithm was used to find dihedral angles that give cyclic structures, the energy was computed for these structures, the lowerenergy structures were classified into conformational families, the energy was minimized for the lowestenergy member of each family, and finally, the structures from energy minimization were reclassified. Analysis revealed seven distinct conformational families that contain reverse turns. The families differ in the position of the turns in the primary sequence; frame-shifted turns are observed at each possible position.