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Cyclic Peptides from the Loop Region of the Laminin α4 Chain LG4 Module Show Enhanced Biological Activity over Linear Peptides †

✍ Scribed by Yokoyama, Fumiharu; Suzuki, Nobuharu; Haruki, Masahiro; Nishi, Norio; Oishi, Shinya; Fujii, Nobutaka; Utani, Atsushi; Kleinman, Hynda K.; Nomizu, Motoyoshi


Book ID
126905962
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
203 KB
Volume
43
Category
Article
ISSN
0006-2960

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Laminin alpha1 chain LG4 module is multifunctional and interacts with syndecans and integrin alpha2beta1 via AG73 (RKRLQVQLSIRT) and EF-I (DYATLQLQEGRLHFMFDLG) sites, respectively. Here, we conjugated the AG73 and EF1zz (ATLQLQEGRLHFXFDLGKGR, X: Nle) peptides on a chitosan membrane in various ratios