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Cyclic Peptide Inhibitors of Phosphatidylinositol 3-Kinase p85 SH2 Domain Binding

✍ Scribed by T.R. Burke; M. Nomizu; A. Otaka; M.S. Smyth; P.P. Roller; R.D. Case; G. Wolf; S.E. Shoelson


Book ID
115574857
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
348 KB
Volume
201
Category
Article
ISSN
0006-291X

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## Abstract To photomodulate the interaction of the phosphatidylinositol 3‐kinase SH3 domain with a peptide ligand, a cyclic peptide (__cyclic__‐1) with a photolabile side chain‐to‐side chain linker was synthesized. The conformation of __cyclic__‐1 differs from that of the parent linear peptide, bu