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Cyclic nucleotide modulation of Na+ and K+ currents in the isolated node of Ranvier

✍ Scribed by Tina L. Seelig; Joan J. Kendig


Book ID
118867551
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
249 KB
Volume
245
Category
Article
ISSN
0006-8993

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Inhibition of voltage-dependent Na+and K
✍ Neil A. Castle πŸ“‚ Article πŸ“… 1989 πŸ› Springer 🌐 English βš– 911 KB

The effect of forskolin on voltage-activated Na + and K + currents in nodes of Ranvier from the toad, Bufo marinus, has been examined using the vaseline-gap voltageclamp technique. Peak Na + currents (INa) were reduced by 35 % and the rate of decline of Na + current during continuous depolarization