## Abstract A new family of cyclic opioid peptide analogues related to the 1–4 sequence of dermorphin/deltorphin (Tyr‐D‐Aaa^2^‐Phe‐Aaa^4^‐NH~2~) has been synthesized. The synthesis of the linear precursor peptides was accomplished by the solid‐phase method and ring formation was achieved via a urei
Cyclic enkephalin and dermorphin analogues containing a carbonyl bridge
✍ Scribed by Katarzyna Filip; Marta Oleszczuk; Jacek Wójcik; Nga N. Chung; Peter W. Schiller; Danuta Pawlak; Agnieszka Zieleniak; Agnieszka Parcińska; Ewa Witkowska; Professor Jan Izdebski
- Book ID
- 105360427
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 149 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.613
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A novel type of cyclic opioid peptide analogue, cyclo[N epsilon,N epsilon'-carbonyl-D-Lys2,Lys5]enkephalinamide, was prepared from a linear precursor peptide. The peptide was synthesized on the Merrified resin and also by a combination of the solid-phase technique and the classical method in solutio
## Abstract Six novel cyclic enkephalin analogues have been synthesized. Cyclization of the linear peptides containing basic amino acid residues in position 2 and 5 was achieved by treatment with bis(4‐nitrophenyl)carbonate. It was found that some of the compounds exibit unusually high __µ__‐opioid
## Abstract Six cyclic peptides related to dermorphin(1–7) have been synthesized. The synthesis of linear peptides containing diamino acid residues in positions 2 and 4 was carried out on a 4‐methylbenzhydrylamine resin, and cyclization was achieved by treatment with bis‐(4‐nitrophenyl)carbonate to