Cyclic antimicrobial R-, W-rich peptides: the role of peptide structure andE. coliouter and inner membranes in activity and the mode of action
✍ Scribed by Christof Junkes; Richard D. Harvey; Kenneth D. Bruce; Rudolf Dölling; Mojtaba Bagheri; Margitta Dathe
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 444 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1432-1017
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## Abstract Recently the peptide Hy‐a1 (IFGAILPLALGALKNLIK), with antimicrobial activity, was isolated from the skin secretion of the frog Hypsiboas albopunctatus. The aim of the present work was to evaluate four analogues with introduction of acetyl group, Asp or Lys at the N‐terminus of antimicro
under 4.5 kHz MAS. Two-dimensional LG-CP and DIPSHIFT experiments were used to measure CÀH dipolar couplings and the ROCSA experiment was used to measure the 13 C NMR CSA values. Further details of orientation simulations are given in the Supporting Information.