๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Cyclic analog of ethacrynic acid

โœ Scribed by M. Brawner Floyd; George R. Allen Jr.

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
218 KB
Volume
59
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

โœฆ Synopsis

The @-unsaturated ketone (4,4-dimethyl-2-ethyl-1 [4H]naphthalenon-6-y1)oxyacetic acid (III), a cyclic analog of ethacrynic acid, has been prepared, and its diuretic activity on oral administration to rats and dogs has been evaluated. No significant activity was observed.

Keyphrases 0 Ethacrynic acid cyclic analog-synthesis Diuretic activity-ethacrynic acid analog 0 UV spectrophotometryidentity

๐Ÿ“œ SIMILAR VOLUMES

Polarographic determination of ethacryni
Polarographic determination of ethacrynic acid
โœ Edward M. Cohen ๐Ÿ“‚ Article ๐Ÿ“… 1971 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 327 KB

Polarography was applied to the analysis of ethacrynic acid in the presence of its principal degradation product, a dimer. The application of the polarographic assay to dosage forms is discussed, and some stability data are given. Keyphrases 0 Ethacrynic acid-polarographic assay, dosage forms 0 Pol

Modulation of doxorubicin cytotoxicity b
Modulation of doxorubicin cytotoxicity by ethacrynic acid
โœ Sanjay Awasthi; Sharad S. Singhal; Nong-gao He; Meena Chaubey; Piotr Zimniak; Sa ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 827 KB

Energy-dependent membrane efflux pumps have been implicated in mediating resistance to doxorubicin (DOX). Membranetransport mechanisms distinct from P-glycoprotein, capable of transporting DOX and glutathione conjugates have been yeported in human cells. Since glutathione-conjugate-forming compounds