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Cyclic AMP-mediated modulation of immunoglobulin production in B cells by prostaglandin E1

โœ Scribed by Christina L. Patke; Frank M. Orson; William T. Shearer


Book ID
113134704
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
685 KB
Volume
137
Category
Article
ISSN
0008-8749

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Addition of prostaglandin E1 (PGE1) to quiescent cultures of Swiss 3T3 cells rapidly elevates the intracellular levels of cAMP and increases the activity of adenylate cyclase in particulate fractions of these cells. In the presence of insulin, PGE1 stimulates the reinitiation of DNA synthesis. Both