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Cyclic AMP levels in temperature sensitive SV40 transformed cell lines

✍ Scribed by Stuart J. Burstin; Hartmut C. Renger; Claudio Basilico

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
399 KB
Volume
84
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

The cAMP levels of the 3T3 cell line and its transformed derivatives were determined. The level was found to be lower in transformed cell lines than in parental 3T3 and to decrease at confluence in all cell lines tested. SV40 transformed 3T3 cell lines which are temperature sensitive in growth control were found to have lower cAMP levels than 3T3, but these levels were not temperature dependent. Retransformation of these cell lines by murine sarcoma virus did not markedly affect their cAMP levels.

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