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Cyclic AMP inhibits c-Ha-ras protooncogene expression, and DNA synthesis in rat aortic smooth muscle cells

✍ Scribed by D. N. Sadhu; K. S. Ramos


Publisher
Springer
Year
1993
Tongue
English
Weight
601 KB
Volume
49
Category
Article
ISSN
1420-682X

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The effects of two adcnosinc analogs on cyclic AMP (CAMP) accumulation and DNA synthesis were studied in cultured smooth muscle cells (SMCs) isolated from adult and neonatal rat arteries. N-ethylcarboxamido adenosine (NECA) dosedependently increased intracellular CAMP levels and appeared to be more