✦ LIBER ✦

Cyclic AMP increase the Na+permeability of the avian erythrocyte membrane by a process which does not involve protein phosphorylation

✍ Scribed by Malcom Weller; Wilma Laing

Publisher: Springer
Year: 1978
Tongue: English
Weight: 443 KB
Volume: 20
Category: Article
ISSN: 0300-8177
DOI: 10.1007/bf00241390

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✦ Synopsis

Preparations of avian erythrocyte plasma membranes have been made which are in the form of sealed vesicles. Using these preparations the permeability of the membranes to N+, K+, Mg2+ and Ca2+ was measured. Monobutyryl cyclic AMP and cyclic AMP increased the permeability to Na+ and Ca+ under conditions where no protein phosphorylation could occur. The only effect of phosphorylation of membrane proteins was to reduce Ca+ permeability. It is thus concluded that cyclic AMP increases Na+ permeability in the avian erythroycte by a direct effect which does not involve protein phosphorylation.