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Cyclic AMP downregulates c-myc expression by inhibition of transcript initiation in human B-precursor Reh cells

✍ Scribed by Kristin Brevik Andersson; Kjetil Taskén; Heidi Kill Blomhoff

Book ID
115930389
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
838 KB
Volume
337
Category
Article
ISSN
0014-5793

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Induction of cyclic AMP synthesis by forskolin is followed by a reduction in the expression of c-myc messenger RNA and inhibition of 3H-thymidine incorporation in human fibroblasts
✍ Nils-Erik Heldin; Ylva Paulsson; Karin Forsberg; Carl-Henrik Heldin; Bengt Weste 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 785 KB

We have studied the effect of increased intracellular levels of cyclic AMP on the growth response to platelet-derived growth factor (PDGF) of human foreskin fibroblasts in culture. It was found that forskolin, a potent stimulator of adenylate cyclase activity, inhibits the stimulatory effect of PDGF