## Abstract A somatic cell genetic approach has been used to evaluate the role of cyclic AMP‐dependent protein kinase in ACTH action on adrenal steroidogenesis. A mutant clone, 8BrcAMP^r^‐1, previously was isolated from an ACTH‐sensitive adrenocortical tumor cell line (clone Y1) following mutagenes
Cyclic AMP-dependent protein kinases and cAMP-binding proteins in human mammary tumor MCF-7 cells
✍ Scribed by W. M. Küng; K. Handloser; U. Eppenberger
- Publisher
- Springer
- Year
- 1984
- Tongue
- English
- Weight
- 468 KB
- Volume
- 234
- Category
- Article
- ISSN
- 0003-9128
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Activation of the cAMP signaling pathway in lymphoid cells is known to inhibit cell proliferation of T and B cells as well as cytotoxicity of natural killer (NK) cells. In order to find suitable model systems to study cAMP-mediated processes, we have examined the expression of cAMP-dependent protein
The drug transporter P-glycoprotein (P-gp) appears to play an important role in the ability of tumor cells to evade killing by chemotherapeutic agents. Using pharmacological inhibitors of cAMP-dependent protein kinase (PKA), it has been suggested that, similar to rodent model systems, the human P-gp
## Abstract Previous studies demonstrated that, upon attaining confluence, a clone of the renal epithelial cell, LLC‐PK~1~, expressed progressively binding sites for the lectin Dolichos biflorus agglutinin (DBA) at the apical cell surface. Activation of cAMP‐dependent protein kinase enhanced surfac