Cyclic-AMP-Dependent Protein Kinase Activity Is Not Required by Parathyroid Hormone to Stimulate Phosphoinositide Signaling in Chondrocytes but Is Required to Transduce the Hormone′s Proliferative Effect

Role of diacylglycerol (DAG) in hormonal

Role of diacylglycerol (DAG) in hormonal induction of S phase in hepatocytes: The DAG-dependent protein kinase C pathway is not activated by epidermal growth factor (EGF), but is involved in mediating the enhancement of responsiveness to EGF by vasopressin, angiotensin II, and norepinephrine

✍ Olav F. Dajani; Dagny Sandnes; Øyvind Melien; Firous Rezvani; Laila S. Nilssen; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB 👁 3 views

The role of diacylglycerol (DAG) in hormonal induction of S phase was investigated in primary cultures of rat hepatocytes. In this model, several agonists that bind to G protein-coupled receptors act as comitogens when added to the cells soon after plating (i.e., in Go/early Gl phase), while the cel