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Cyclic AMP alleviates endoplasmic stress and programmed cell death induced by lipopolysaccharides in human endothelial cells

✍ Scribed by Frank A. Schildberg; Susanne Schulz; Frank Dombrowski; Thomas Minor


Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
323 KB
Volume
320
Category
Article
ISSN
0302-766X

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## Abstract Nitric oxide (NO) is cytotoxic for human SH‐SY5Y neuroblastoma cells. While nuclear condensation was visible in cells treated with nitric oxide donors, we observed that the plasma membrane remained intact, indicating that NO induced apoptotic cell death. We analyzed the NO‐induced apopt