✦ LIBER ✦
Cycle delay in irradiated cytochalasin-induced polykaryons. Does cytoskeleton status affect cell cycle checkpoints?
✍ Scribed by H.E. Davies; J.B. Court
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 326 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1065-6995
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✦ Synopsis
Abstract
Following exposure of CHO‐K1 cells to^137^Cs irradiation at doses up to 20Gy, a delay in G~2~ was observed to occur in cells permitted to divide normally, while cells induced to become giants by means of cytochalasin B demonstrated a minimal delay in the transition 2C–8C suggesting that the inhibition of cytokinesis results in modification of one or more cell cycle checkpoints. We postulate that this may occur as a consequence of damage tolerance, or by a feedback loop resulting from the reorganisation of the cytoskeleton that precludes cytokinesis.