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Cyanoguanidine bioisosteres in potassium channel openers: Evaluation of 3,4-disubstituted-1,2,5-thiadiazole-1-oxides

✍ Scribed by Heinrich J. Schostarez; Theresa J. O'Sullivan; Vincent E. Groppi; Loretta A. Cipkus-Dubray

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 252 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00397-6

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✦ Synopsis

Bioisostefic substitution of the cyanoguanidine group found in pinacidil (1) with a 3,4-diamino-l,2,5thiadiazole-l-oxide moiety and replacement of the 4-aminopyridine group with a 3,5-dichlorophenyl group has resulted in a new structural class of potassium channel opener (PCO).

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