𝔖 Bobbio Scriptorium
✦   LIBER   ✦

CXCR7 is inducible by HTLV-1 Tax and promotes growth and survival of HTLV-1-infected T cells

✍ Scribed by Zhe Jin; Daisuke Nagakubo; Aiko-Konno Shirakawa; Takashi Nakayama; Akiko Shigeta; Kunio Hieshima; Yasuaki Yamada; Osamu Yoshie

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
357 KB
Volume
125
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Human T‐lymphotropic virus type 1 (HTLV‐1), the etiological agent of adult T‐cell leukemia (ATL), encodes the potent transcriptional activator Tax, which is required for HTLV‐1‐induced immortalization of T cells. CXCR7 is an atypical chemokine receptor frequently expressed by tumor cells and known to promote cell growth and survival. We found that HTLV‐1‐immortalized T cells expressing Tax consistently expressed CXCR7. Induction of Tax in JPX‐9 upregulated CXCR7. Wild‐type Tax efficiently activated the CXCR7 promoter via a proximal NF‐κB site, while a mutant Tax selectively defective in NF‐κB activation did not. CCX754, a synthetic CXCR7 antagonist, inhibited cell growth and increased apoptosis of HTLV‐1‐immortalized T cells. Knockdown of CXCR7 by small interfering RNA also reduced cell growth. Stable expression of CXCR7 in a CXCR7‐negative ATL cell line promoted cell growth and survival. Taken together, CXCR7 is inducible by Tax and may play an important role in HTLV‐1‐induced immortalization of T cells by promoting growth and survival of HTLV‐1‐infected T cells. © 2009 UICC

📜 SIMILAR VOLUMES

Activation of cyclin D1 and D2 promoters
Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I tax protein is associated with IL-2–independent growth of T cells
✍ Naoki Mori; Masahiro Fujii; Michael Hinz; Katsushi Nakayama; Yasuaki Yamada; Shu 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 444 KB

## Abstract Our aim was to examine the involvement of G~1~ cell‐cycle regulators in cell growth dysregulation induced by HTLV‐I. Compared to uninfected cells, higher expression levels of cyclin D1 and D2 mRNA were detected in HTLV‐I–infected T‐cell lines, which were at least in part mediated by the

Target epitopes of HTLV-1 recognized by
Target epitopes of HTLV-1 recognized by class I MHC-restricted cytotoxic T lymphocytes in patients with myelopathy and spastic paraparesis and infected patients with autoimmune disorders
✍ Tomohiro Kozako; Masaki Akimoto; Shingo Toji; Yohann White; Susumu Suzuki; Takeh 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 407 KB

## Abstract Human T‐cell lymphotropic virus type I (HTLV‐1) causes adult T‐cell leukemia/lymphoma and HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). The different patterns of clinical diseases are thought to be linked to immunogenetic host factors. A variety of autoimmune dise