## Abstract Human prostate cancers (PCa) express great variability in their ability to metastasize to bone. The identification of molecules associated with aggressive phenotypes will help to define PCa subsets and will ultimately lead to better treatment strategies. The chemokine stromal‐derived fa
✦ LIBER ✦
CXCL12–CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion
✍ Scribed by Singh, Shailesh; Singh, Udai P; Grizzle, William E; Lillard, James W
- Book ID
- 109885821
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 209 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0023-6837
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## Abstract The zinc metalloprotease, endothelin‐converting enzyme‐1 (ECE‐1), which converts the mitogenic peptide endothelin‐1 (ET‐1) from its biologically inactive precursor big‐ET‐1, is commonly upregulated in prostate cancer (PC) cells. Consequently, we have sought to suppress ECE‐1 expression