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Cutaneous ulcers: An unusual manifestation of inherited thrombophilia

✍ Scribed by Clio P. Mavragani; Dimitris Pikazis; Kyriaki Aroni; Spiros Paikos; Michalis Voulgarelis

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 100 KB
Volume: 76
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.20077

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✦ Synopsis

Abstract

We report two cases with cutaneous lesions found to be associated with factor V Leiden mutation and low S protein levels. At the time of presentation, no other symptoms were reported. Histopathology of both lesions revealed the presence of widespread intravascular thrombi. The therapeutic response to oral anticoagulants in the first case was dramatic, leading to complete healing of the lesions. Inherited causes of thrombophilia manifested as cutaneous lesions, although rare, should be considered in the differential diagnosis of occlusive vasculopathy. Am J Hematol 76:139–142, 2004. © 2004 Wiley‐Liss, Inc.

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