✦ LIBER ✦

Cutaneous toxicity following the administration of dactinomycin

✍ Scribed by Coppes, Max J.; Jorgenson, Keith; Arlette, John P.

Book ID: 101218955
Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 272 KB
Volume: 29
Category: Article
ISSN: 0098-1532
DOI: 10.1002/(sici)1096-911x(199709)29:3<226::aid-mpo13>3.0.co;2-b

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✦ Synopsis

Dactinomycin (AMD) is an effective drug in the management of several malignant disorders and has been used for almost 40 years. Skin and subcutaneous toxicities following extravasation are well known and can be harmful. Similarly radiation-recall is a well established phenomenon following the administration of AMD. We report a patient who developed a localized brawny erythema in the crural folds and the axillae, likely due to AMD. This rare skin complication of AMD seems to benefit from topical corticosteroid treatment, although postinflammatory hyperpigmentation may take months to disappear.

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