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Cutaneous fibrosis induced by docetaxel : A case report

✍ Scribed by Mark G. Cleveland; B. S. Ajaikumar; Rohini Reganti

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
381 KB
Volume
88
Category
Article
ISSN
0008-543X

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✦ Synopsis

Background:

Docetaxel is a taxoid antineoplastic agent approved for use in the treatment of metastatic breast carcinoma. the current study reports an unusual case of generalized cutaneous fibrosis in a 39-year-old white female after treatment with 18 cycles of docetaxel for metastatic breast carcinoma.

Methods:

Cutaneous fibrosis represents a rare and unique reaction associated with the cyclic use of docetaxel. the reaction is manifested by a distinct sequence of events involving pronounced edema followed by the rapid development of cutaneous fibrosis in dependent areas.

Results:

Cessation of therapy results in dramatic reversal of the fibrotic process.

Conclusions:

This case report further substantiates the belief that docetaxel represents one of a very limited number of agents that appear capable of giving rise to scleroderma-like features.

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