Cutaneous allergic reaction to intramuscular vitamin K1

✍ Scribed by Deanna A Wong; Susanne Freeman

• Book ID: 104468942
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 315 KB
• Volume: 40
• Category: Article
• ISSN: 0004-8380
• DOI: 10.1046/j.1440-0960.1999.00348.x

✦ Synopsis

A 40‐year‐old woman with no pre‐existing hepatic disease developed a cutaneous allergic reaction to intramuscular vitamin K1. She received this medication prophylactically prior to surgery, developed severe localized, and subsequently generalized, dermatitis, beginning 5 days after administration of the Konakion Cremophor‐EL form of vitamin K1 by intramuscular injection at four sites on her thighs. Investigation by patch and intradermal testing revealed delayed‐type hypersensitivity to Konakion Cremophor‐EL, Konakion Mixed Micelles and pure vitamin K1, but not Cremophor‐EL vehicle alone. This case is unusual because the patient was also shown to be patch test positive to vitamin K3 sodium bisulfite.