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Cut5 is a component of the UV-responsive DNA damage checkpoint in fission yeast

โœ Scribed by Verkade, H. M. ;O'Connell, M. J.


Book ID
106133177
Publisher
Springer
Year
1998
Tongue
English
Weight
359 KB
Volume
260
Category
Article
ISSN
0026-8925

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The protein kinase Chk1 is essential for the DNA damage checkpoint. Cells lacking Chk1 are hypersensitive to DNA-damaging agents such as UV light and -irradiation because they fail to arrest the cell cycle when DNA damage is generated. Phosphorylation of Chk1 occurs after DNA damage and is dependent