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Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins

✍ Scribed by David J Segal; Carlos F Barbas III

Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 116 KB
Volume: 12
Category: Article
ISSN: 0958-1669
DOI: 10.1016/s0958-1669(01)00272-5

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✦ Synopsis

Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.

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