𝔖 Bobbio Scriptorium
✦   LIBER   ✦

[Current Topics in Microbiology and Immunology] Thymic Development and Selection of T Lymphocytes Volume 373 || Central Tolerance Induction

✍ Scribed by Boehm, Thomas; Takahama, Yousuke

Book ID
127195646
Publisher
Springer Berlin Heidelberg
Year
2013
Tongue
German
Weight
437 KB
Edition
2014
Category
Article
ISBN
3642402526

No coin nor oath required. For personal study only.

✦ Synopsis

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

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