[Current Topics in Microbiology and Immunology] Phosphoinositide 3-kinase in Health and Disease Volume 347 || From the Bench to the Bed Side: PI3K Pathway Inhibitors in Clinical Development

✍ Scribed by Rommel, Christian; Vanhaesebroeck, Bart; Vogt, Peter K.

• Book ID: 111858509
• Publisher: Springer Berlin Heidelberg
• Year: 2010
• Tongue: German
• Weight: 377 KB
• Edition: 2011
• Category: Article
• ISBN: 3642148166
• DOI: 10.1007/82_2010_60

✦ Synopsis

PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target