Current Topics in Innate Immunity II

✍ Scribed by Antonio Inforzato, Barbara Bottazzi (auth.), John D. Lambris, George Hajishengallis (eds.)

Publisher: Springer-Verlag New York
Year: 2012
Tongue: English
Leaves: 369
Series: Advances in Experimental Medicine and Biology 946
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Mounting evidence in the past decade indicates that innate immunity mediates functions above and beyond first-line defense against infection. It is now appreciated that innate immune mechanisms are critically involved in the development of adaptive immunity and, moreover, the regulation of diverse physiological and homeostatic processes. The latter explains why deregulation of innate immunity may lead to pathological disorders that are not necessarily or directly related to host defense. This Volume compiles the latest advances in this rapidly evolving field as presented by eminent scientists at the 7th International Aegean Conference on Innate Immunity in Rhodes, Greece. It includes topics related to the biology and function of Toll-like and other pattern-recognition receptors, complement and its crosstalk with other physiological systems, inflammatory mechanisms and diseases, natural killer cells, and the cooperative interplay between innate and adaptive immune cells. This book is an excellent source of information for researchers and clinicians with interests in immunology, host-microbe interactions, and infectious and inflammatory diseases.

✦ Table of Contents

Front Matter....Pages i-xvii
Pentraxins in Humoral Innate Immunity....Pages 1-20
Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution....Pages 21-36
The Role of Innate Immunity in Trafficking of Hematopoietic Stem Cells—An Emerging Link Between Activation of Complement Cascade and Chemotactic Gradients of Bioactive Sphingolipids....Pages 37-54
Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds....Pages 55-68
Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity....Pages 69-85
A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects....Pages 87-112
Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins....Pages 113-133
Granzyme B: A New Crossroad of Complement and Apoptosis....Pages 135-146
Role of C3, C5 and Anaphylatoxin Receptors in Acute Lung Injury and in Sepsis....Pages 147-159
Complement Involvement in Neovascular Ocular Diseases....Pages 161-183
Platelets, Complement, and Contact Activation: Partners in Inflammation and Thrombosis....Pages 185-205
Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection....Pages 207-221
Function of Act1 in IL-17 Family Signaling and Autoimmunity....Pages 223-235
Differential Effect of Inhibiting MD-2 and CD14 on LPS- Versus Whole E. coli Bacteria-Induced Cytokine Responses in Human Blood....Pages 237-251
Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases....Pages 253-275
Monocyte-derived Inflammatory Dendritic Cells in the Granuloma During Mycobacterial Infection....Pages 277-293
NK/DC Crosstalk in Anti-viral Response....Pages 295-308
Innate-Adaptive Crosstalk: How Dendritic Cells Shape Immune Responses in the CNS....Pages 309-333
Nutritional Immunity: Homology Modeling of Nramp Metal Import....Pages 335-351
Back Matter....Pages 353-354

✦ Subjects

Immunology; Microbiology; Infectious Diseases; Virology; Pharmacology/Toxicology

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